Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis

BACKGROUND: Pancreatic ductular adenocarcinoma (PDAC) is among the most dreadful of malignancies, in part due to the lack of efficacious chemotherapy. Immune checkpoint inhibitors, including anti-programmed cell death 1 (anti-PD-1) antibodies, are novel promising forms of systemic immunotherapy. In...

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Detalles Bibliográficos
Autores principales: Ho, Tuyen Thuy Bich, Nasti, Alessandro, Seki, Akihiro, Komura, Takuya, Inui, Hiiro, Kozaka, Takashi, Kitamura, Yoji, Shiba, Kazuhiro, Yamashita, Taro, Yamashita, Tatsuya, Mizukoshi, Eishiro, Kawaguchi, Kazunori, Wada, Takashi, Honda, Masao, Kaneko, Shuichi, Sakai, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668383/
https://www.ncbi.nlm.nih.gov/pubmed/33188035
http://dx.doi.org/10.1136/jitc-2020-001367

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