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Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis
BACKGROUND: Several studies have explored the prognostic value of MicroRNA-153 (miR-153) in various cancers, but obtained inconsistent results. Thus, we conducted a meta-analysis to assess the prognostic significance of miR-153 for patients with cancer. METHODS: Eligible studies were identified by s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668496/ https://www.ncbi.nlm.nih.gov/pubmed/33181653 http://dx.doi.org/10.1097/MD.0000000000022833 |
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author | Huang, Mengqin Li, Chengfa Kong, Fanliang Wu, Yan Yuan, Qianqian Hu, Lixia |
author_facet | Huang, Mengqin Li, Chengfa Kong, Fanliang Wu, Yan Yuan, Qianqian Hu, Lixia |
author_sort | Huang, Mengqin |
collection | PubMed |
description | BACKGROUND: Several studies have explored the prognostic value of MicroRNA-153 (miR-153) in various cancers, but obtained inconsistent results. Thus, we conducted a meta-analysis to assess the prognostic significance of miR-153 for patients with cancer. METHODS: Eligible studies were identified by searching the online databases Pubmed, Embase, Web of Science, Medline,and the China National Knowledge Infrastructure (CNKI) up to March 2020. Hazard ratios (HRs) with 95% CIs and were calculated to clarify the correlation between miR-153 expression and prognosis of different cancers. Odds ratios (ORs) with 95% CI were selected to appraise the correlation between miR-153 with clinicopathological characteristics of cancer patients. RESULTS: In total, 933 patients from 11 articles were enrolled in our meta-analysis. The results revealed that low miR-153 expression was significantly correlated with poor overall survival (OS) (HR = 2.45, 95% CI = 1.66–3.63, P < .001), but not with disease-free survival (DFS) (HR = 1.67, 95% CI = 0.45–6.19, P = .442). Subgroup analysis found that low miR-153 expression was associated with worse OS in the reported directly from articles group (HR = 2.67, 95% CI: 1.32–5.37, P = .006), survival curves group (HR = 2.10, 95% CI: 1.56–2.84, P < .001), digestive system tumor (HR = 2.76, 95% CI: 1.73–4.41, P < .001), and breast cancer (HR = 4.01, 95% CI: 1.46–11.04, P = .007). Moreover, cancer patients with low miR-153 expression were prone to poor tumor differentiation(poor vs well+moderate, OR = 2.41, 95% CI = 1.52–3.82, P < .001), earlier lymph node metastasis (present vs absent, OR = 2.19, 95% CI = 1.12–4.25, P = .021) and earlier distant metastasis (present vs absent,OR = 8.24, 95% CI = 2.93–23.21, P < .001), but not associated with age,gender and TNM stage. CONCLUSIONS: This meta-analysis indicated that low miR-153 expression is associated with poor prognosis. miR-153 may serve as an effective predictive biomarker for tumor prognosis, especially for digestive system tumor and breast cancer. |
format | Online Article Text |
id | pubmed-7668496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-76684962020-11-17 Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis Huang, Mengqin Li, Chengfa Kong, Fanliang Wu, Yan Yuan, Qianqian Hu, Lixia Medicine (Baltimore) 5700 BACKGROUND: Several studies have explored the prognostic value of MicroRNA-153 (miR-153) in various cancers, but obtained inconsistent results. Thus, we conducted a meta-analysis to assess the prognostic significance of miR-153 for patients with cancer. METHODS: Eligible studies were identified by searching the online databases Pubmed, Embase, Web of Science, Medline,and the China National Knowledge Infrastructure (CNKI) up to March 2020. Hazard ratios (HRs) with 95% CIs and were calculated to clarify the correlation between miR-153 expression and prognosis of different cancers. Odds ratios (ORs) with 95% CI were selected to appraise the correlation between miR-153 with clinicopathological characteristics of cancer patients. RESULTS: In total, 933 patients from 11 articles were enrolled in our meta-analysis. The results revealed that low miR-153 expression was significantly correlated with poor overall survival (OS) (HR = 2.45, 95% CI = 1.66–3.63, P < .001), but not with disease-free survival (DFS) (HR = 1.67, 95% CI = 0.45–6.19, P = .442). Subgroup analysis found that low miR-153 expression was associated with worse OS in the reported directly from articles group (HR = 2.67, 95% CI: 1.32–5.37, P = .006), survival curves group (HR = 2.10, 95% CI: 1.56–2.84, P < .001), digestive system tumor (HR = 2.76, 95% CI: 1.73–4.41, P < .001), and breast cancer (HR = 4.01, 95% CI: 1.46–11.04, P = .007). Moreover, cancer patients with low miR-153 expression were prone to poor tumor differentiation(poor vs well+moderate, OR = 2.41, 95% CI = 1.52–3.82, P < .001), earlier lymph node metastasis (present vs absent, OR = 2.19, 95% CI = 1.12–4.25, P = .021) and earlier distant metastasis (present vs absent,OR = 8.24, 95% CI = 2.93–23.21, P < .001), but not associated with age,gender and TNM stage. CONCLUSIONS: This meta-analysis indicated that low miR-153 expression is associated with poor prognosis. miR-153 may serve as an effective predictive biomarker for tumor prognosis, especially for digestive system tumor and breast cancer. Lippincott Williams & Wilkins 2020-11-13 /pmc/articles/PMC7668496/ /pubmed/33181653 http://dx.doi.org/10.1097/MD.0000000000022833 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Huang, Mengqin Li, Chengfa Kong, Fanliang Wu, Yan Yuan, Qianqian Hu, Lixia Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title | Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title_full | Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title_fullStr | Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title_full_unstemmed | Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title_short | Prognostic and clinicopathological significance of MicroRNA-153 in human cancers: A meta-analysis |
title_sort | prognostic and clinicopathological significance of microrna-153 in human cancers: a meta-analysis |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668496/ https://www.ncbi.nlm.nih.gov/pubmed/33181653 http://dx.doi.org/10.1097/MD.0000000000022833 |
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