Cargando…

A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model

BACKGROUND: With large numbers of COVID-19 patients requiring mechanical ventilation and ventilators possibly being in short supply, in extremis two patients may have to share one ventilator. Careful matching of patient ventilation requirements is necessary. However, good matching is difficult to ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Plummer, Andrew R., du Bois, Jonathan L., Flynn, Joseph M., Roesner, Jens, Lee, Siu Man, Magee, Patrick, Thornton, Malcolm, Padkin, Andrew, Gill, Harinderjit S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668571/
https://www.ncbi.nlm.nih.gov/pubmed/33196687
http://dx.doi.org/10.1371/journal.pone.0242123
_version_ 1783610509527875584
author Plummer, Andrew R.
du Bois, Jonathan L.
Flynn, Joseph M.
Roesner, Jens
Lee, Siu Man
Magee, Patrick
Thornton, Malcolm
Padkin, Andrew
Gill, Harinderjit S.
author_facet Plummer, Andrew R.
du Bois, Jonathan L.
Flynn, Joseph M.
Roesner, Jens
Lee, Siu Man
Magee, Patrick
Thornton, Malcolm
Padkin, Andrew
Gill, Harinderjit S.
author_sort Plummer, Andrew R.
collection PubMed
description BACKGROUND: With large numbers of COVID-19 patients requiring mechanical ventilation and ventilators possibly being in short supply, in extremis two patients may have to share one ventilator. Careful matching of patient ventilation requirements is necessary. However, good matching is difficult to achieve as lung characteristics can have a wide range and may vary over time. Adding flow restriction to the flow path between ventilator and patient gives the opportunity to control the airway pressure and hence flow and volume individually for each patient. This study aimed to create and validate a simple model for calculating required flow restriction. METHODS AND FINDINGS: We created a simple linear resistance-compliance model, termed the BathRC model, of the ventilator tubing system and lung allowing direct calculation of the relationships between pressures, volumes, and required flow restriction. Experimental measurements were made for parameter determination and validation using a clinical ventilator connected to two test lungs. For validation, differing amounts of restriction were introduced into the ventilator circuit. The BathRC model was able to predict tidal lung volumes with a mean error of 4% (min:1.2%, max:9.3%). CONCLUSION: We present a simple model validated model that can be used to estimate required flow restriction for dual patient ventilation. The BathRC model is freely available; this tool is provided to demonstrate that flow restriction can be readily estimated. Models and data are available at DOI 10.15125/BATH-00816.
format Online
Article
Text
id pubmed-7668571
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-76685712020-11-19 A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model Plummer, Andrew R. du Bois, Jonathan L. Flynn, Joseph M. Roesner, Jens Lee, Siu Man Magee, Patrick Thornton, Malcolm Padkin, Andrew Gill, Harinderjit S. PLoS One Research Article BACKGROUND: With large numbers of COVID-19 patients requiring mechanical ventilation and ventilators possibly being in short supply, in extremis two patients may have to share one ventilator. Careful matching of patient ventilation requirements is necessary. However, good matching is difficult to achieve as lung characteristics can have a wide range and may vary over time. Adding flow restriction to the flow path between ventilator and patient gives the opportunity to control the airway pressure and hence flow and volume individually for each patient. This study aimed to create and validate a simple model for calculating required flow restriction. METHODS AND FINDINGS: We created a simple linear resistance-compliance model, termed the BathRC model, of the ventilator tubing system and lung allowing direct calculation of the relationships between pressures, volumes, and required flow restriction. Experimental measurements were made for parameter determination and validation using a clinical ventilator connected to two test lungs. For validation, differing amounts of restriction were introduced into the ventilator circuit. The BathRC model was able to predict tidal lung volumes with a mean error of 4% (min:1.2%, max:9.3%). CONCLUSION: We present a simple model validated model that can be used to estimate required flow restriction for dual patient ventilation. The BathRC model is freely available; this tool is provided to demonstrate that flow restriction can be readily estimated. Models and data are available at DOI 10.15125/BATH-00816. Public Library of Science 2020-11-16 /pmc/articles/PMC7668571/ /pubmed/33196687 http://dx.doi.org/10.1371/journal.pone.0242123 Text en © 2020 Plummer et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Plummer, Andrew R.
du Bois, Jonathan L.
Flynn, Joseph M.
Roesner, Jens
Lee, Siu Man
Magee, Patrick
Thornton, Malcolm
Padkin, Andrew
Gill, Harinderjit S.
A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title_full A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title_fullStr A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title_full_unstemmed A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title_short A simple method to estimate flow restriction for dual ventilation of dissimilar patients: The BathRC model
title_sort simple method to estimate flow restriction for dual ventilation of dissimilar patients: the bathrc model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668571/
https://www.ncbi.nlm.nih.gov/pubmed/33196687
http://dx.doi.org/10.1371/journal.pone.0242123
work_keys_str_mv AT plummerandrewr asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT duboisjonathanl asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT flynnjosephm asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT roesnerjens asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT leesiuman asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT mageepatrick asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT thorntonmalcolm asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT padkinandrew asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT gillharinderjits asimplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT plummerandrewr simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT duboisjonathanl simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT flynnjosephm simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT roesnerjens simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT leesiuman simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT mageepatrick simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT thorntonmalcolm simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT padkinandrew simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel
AT gillharinderjits simplemethodtoestimateflowrestrictionfordualventilationofdissimilarpatientsthebathrcmodel