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Gain-of-function assay for SARS-CoV-2 M(pro) inhibition in living cells

The main protease, M(pro), of SARS-CoV-2 is required to cleave the viral polyprotein into precise functional units for virus replication and pathogenesis. Here we demonstrate a quantitative reporter for M(pro) function in living cells, in which protease inhibition by genetic or chemical methods resu...

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Detalles Bibliográficos
Autores principales:	Moghadasi, Seyad Arad, Becker, Jordan T., Belica, Christopher, Wick, Chloe, Brown, William L., Harris, Reuben S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668733/ https://www.ncbi.nlm.nih.gov/pubmed/33200129 http://dx.doi.org/10.1101/2020.11.09.375139

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