Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19

Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibitors constrain host NEU activity, surface sialic aci...

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Detalles Bibliográficos
Autores principales: de Oliveira Formiga, Rodrigo, Amaral, Flávia C., Souza, Camila F., Mendes, Daniel A. G. B., Wanderley, Carlos W. S., Lorenzini, Cristina B., Santos, Adara A., Antônia, Juliana, Faria, Lucas F., Natale, Caio C., Paula, Nicholas M., Silva, Priscila C. S., Fonseca, Fernanda R., Aires, Luan, Heck, Nicoli, Starick, Márick R., Queiroz-Junior, Celso M., Santos, Felipe R. S., de Souza, Filipe R. O., Costa, Vivian V., Barroso, Shana P. C., Morrot, Alexandre, Van Weyenbergh, Johan, Sordi, Regina, Alisson-Silva, Frederico, Cunha, Fernando Q., Rocha, Edroaldo L., Chollet-Martin, Sylvie, Hurtado-Nedelec, Maria Margarita, Martin, Clémence, Burgel, Pierre-Régis, Mansur, Daniel S., Maurici, Rosemeri, Macauley, Matthew S., Báfica, André, Witko-Sarsat, Véronique, Spiller, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668734/
https://www.ncbi.nlm.nih.gov/pubmed/33200130
http://dx.doi.org/10.1101/2020.11.12.379115

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