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Cytotoxic T cells swarm by homotypic chemokine signalling
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669268/ https://www.ncbi.nlm.nih.gov/pubmed/33046212 http://dx.doi.org/10.7554/eLife.56554 |
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author | Galeano Niño, Jorge Luis Pageon, Sophie V Tay, Szun S Colakoglu, Feyza Kempe, Daryan Hywood, Jack Mazalo, Jessica K Cremasco, James Govendir, Matt A Dagley, Laura F Hsu, Kenneth Rizzetto, Simone Zieba, Jerzy Rice, Gregory Prior, Victoria O'Neill, Geraldine M Williams, Richard J Nisbet, David R Kramer, Belinda Webb, Andrew I Luciani, Fabio Read, Mark N Biro, Maté |
author_facet | Galeano Niño, Jorge Luis Pageon, Sophie V Tay, Szun S Colakoglu, Feyza Kempe, Daryan Hywood, Jack Mazalo, Jessica K Cremasco, James Govendir, Matt A Dagley, Laura F Hsu, Kenneth Rizzetto, Simone Zieba, Jerzy Rice, Gregory Prior, Victoria O'Neill, Geraldine M Williams, Richard J Nisbet, David R Kramer, Belinda Webb, Andrew I Luciani, Fabio Read, Mark N Biro, Maté |
author_sort | Galeano Niño, Jorge Luis |
collection | PubMed |
description | Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen receptor (CAR) T cells similarly employ intra-population signalling to drive rapid convergence. Thus, CTLs recognising a cognate target can induce a localised mass response by amplifying the direct recruitment of additional T cells independently of other leukocytes. |
format | Online Article Text |
id | pubmed-7669268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-76692682020-11-18 Cytotoxic T cells swarm by homotypic chemokine signalling Galeano Niño, Jorge Luis Pageon, Sophie V Tay, Szun S Colakoglu, Feyza Kempe, Daryan Hywood, Jack Mazalo, Jessica K Cremasco, James Govendir, Matt A Dagley, Laura F Hsu, Kenneth Rizzetto, Simone Zieba, Jerzy Rice, Gregory Prior, Victoria O'Neill, Geraldine M Williams, Richard J Nisbet, David R Kramer, Belinda Webb, Andrew I Luciani, Fabio Read, Mark N Biro, Maté eLife Computational and Systems Biology Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen receptor (CAR) T cells similarly employ intra-population signalling to drive rapid convergence. Thus, CTLs recognising a cognate target can induce a localised mass response by amplifying the direct recruitment of additional T cells independently of other leukocytes. eLife Sciences Publications, Ltd 2020-10-13 /pmc/articles/PMC7669268/ /pubmed/33046212 http://dx.doi.org/10.7554/eLife.56554 Text en © 2020, Galeano Niño et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Galeano Niño, Jorge Luis Pageon, Sophie V Tay, Szun S Colakoglu, Feyza Kempe, Daryan Hywood, Jack Mazalo, Jessica K Cremasco, James Govendir, Matt A Dagley, Laura F Hsu, Kenneth Rizzetto, Simone Zieba, Jerzy Rice, Gregory Prior, Victoria O'Neill, Geraldine M Williams, Richard J Nisbet, David R Kramer, Belinda Webb, Andrew I Luciani, Fabio Read, Mark N Biro, Maté Cytotoxic T cells swarm by homotypic chemokine signalling |
title | Cytotoxic T cells swarm by homotypic chemokine signalling |
title_full | Cytotoxic T cells swarm by homotypic chemokine signalling |
title_fullStr | Cytotoxic T cells swarm by homotypic chemokine signalling |
title_full_unstemmed | Cytotoxic T cells swarm by homotypic chemokine signalling |
title_short | Cytotoxic T cells swarm by homotypic chemokine signalling |
title_sort | cytotoxic t cells swarm by homotypic chemokine signalling |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669268/ https://www.ncbi.nlm.nih.gov/pubmed/33046212 http://dx.doi.org/10.7554/eLife.56554 |
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