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The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation
A short QT interval has been difficult to define, and there is debate whether it exists outside of an extremely small group of individuals with inherited channelopathies and whether it predicts cardiac arrhythmias. The objective was to identify cases with short QT and their consequences. Our hospita...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669358/ https://www.ncbi.nlm.nih.gov/pubmed/33224525 http://dx.doi.org/10.1155/2020/2858149 |
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author | Rabkin, Simon W. Tang, Jacky K. K. |
author_facet | Rabkin, Simon W. Tang, Jacky K. K. |
author_sort | Rabkin, Simon W. |
collection | PubMed |
description | A short QT interval has been difficult to define, and there is debate whether it exists outside of an extremely small group of individuals with inherited channelopathies and whether it predicts cardiac arrhythmias. The objective was to identify cases with short QT and their consequences. Our hospital ECG database was screened for cases with a QTc based on the Bazett formula (QTcBZT) of less than 340 ms. The QTc was recalculated using the spline (QTcRBK) formula, which more accurately adjusts for the heart rate and identifies cases based on percentile distribution of the QT interval. The exclusion criteria were presence of bundle branch block, arrhythmias, or electronic pacemakers. An age- and sex-matched cohort was obtained from individuals with normal QT intervals with the same exclusion criteria. There were 28 cases with a short QTc (QTcRBK < 380 ms). The age was 69.6 ± 14.6 years (mean ± SD) (50% males). The QT interval was 305.7 ± 61.1 ms with QTcRBK 308.4 ± 31.4 ms. Subsequent ECGs showed atrial flutter in 21%, atrial fibrillation in 18%, and atrial tachycardia in 4% of cases. Thus, atrial arrhythmias occurred in 43% of cases. This incidence was significantly (p < 0.0001) greater than the incidence of atrial arrhythmias in age- and sex-matched controls. In conclusion, a short QT interval can be readily identified based on the first percentile of the new QTc formula. A short QTc is an important marker for the development of atrial arrhythmias, including atrial flutter and atrial fibrillation, with the former predominating. It should be part of patient assessment and warrants consideration to develop strategies for detection and prevention of atrial arrhythmias. |
format | Online Article Text |
id | pubmed-7669358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-76693582020-11-19 The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation Rabkin, Simon W. Tang, Jacky K. K. Cardiol Res Pract Research Article A short QT interval has been difficult to define, and there is debate whether it exists outside of an extremely small group of individuals with inherited channelopathies and whether it predicts cardiac arrhythmias. The objective was to identify cases with short QT and their consequences. Our hospital ECG database was screened for cases with a QTc based on the Bazett formula (QTcBZT) of less than 340 ms. The QTc was recalculated using the spline (QTcRBK) formula, which more accurately adjusts for the heart rate and identifies cases based on percentile distribution of the QT interval. The exclusion criteria were presence of bundle branch block, arrhythmias, or electronic pacemakers. An age- and sex-matched cohort was obtained from individuals with normal QT intervals with the same exclusion criteria. There were 28 cases with a short QTc (QTcRBK < 380 ms). The age was 69.6 ± 14.6 years (mean ± SD) (50% males). The QT interval was 305.7 ± 61.1 ms with QTcRBK 308.4 ± 31.4 ms. Subsequent ECGs showed atrial flutter in 21%, atrial fibrillation in 18%, and atrial tachycardia in 4% of cases. Thus, atrial arrhythmias occurred in 43% of cases. This incidence was significantly (p < 0.0001) greater than the incidence of atrial arrhythmias in age- and sex-matched controls. In conclusion, a short QT interval can be readily identified based on the first percentile of the new QTc formula. A short QTc is an important marker for the development of atrial arrhythmias, including atrial flutter and atrial fibrillation, with the former predominating. It should be part of patient assessment and warrants consideration to develop strategies for detection and prevention of atrial arrhythmias. Hindawi 2020-11-08 /pmc/articles/PMC7669358/ /pubmed/33224525 http://dx.doi.org/10.1155/2020/2858149 Text en Copyright © 2020 Simon W. Rabkin and Jacky K. K. Tang. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rabkin, Simon W. Tang, Jacky K. K. The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title | The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title_full | The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title_fullStr | The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title_full_unstemmed | The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title_short | The Short QTc Is a Marker for the Development of Atrial Flutter and Atrial Fibrillation |
title_sort | short qtc is a marker for the development of atrial flutter and atrial fibrillation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669358/ https://www.ncbi.nlm.nih.gov/pubmed/33224525 http://dx.doi.org/10.1155/2020/2858149 |
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