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Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium
BACKGROUND: Elderly patients with pancreatic cancer are underrepresented in clinical trials, resulting in a lack of evidence. OBJECTIVE: The aim of this study was to compare treatment and overall survival (OS) of patients aged ≥ 70 years with stage I–II pancreatic cancer in the EURECCA Pancreas Cons...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669775/ https://www.ncbi.nlm.nih.gov/pubmed/32388741 http://dx.doi.org/10.1245/s10434-020-08539-x |
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author | Groen, Jesse V. Douwes, Tom A. van Eycken, Elizabeth van der Geest, Lydia G. M. Johannesen, Tom B. Besselink, Marc G. Koerkamp, Bas Groot Wilmink, Johanna W. Bonsing, Bert A. Portielje, Johanna E. A. van de Velde, Cornelus J. H. Bastiaannet, Esther Mieog, J. Sven D. |
author_facet | Groen, Jesse V. Douwes, Tom A. van Eycken, Elizabeth van der Geest, Lydia G. M. Johannesen, Tom B. Besselink, Marc G. Koerkamp, Bas Groot Wilmink, Johanna W. Bonsing, Bert A. Portielje, Johanna E. A. van de Velde, Cornelus J. H. Bastiaannet, Esther Mieog, J. Sven D. |
author_sort | Groen, Jesse V. |
collection | PubMed |
description | BACKGROUND: Elderly patients with pancreatic cancer are underrepresented in clinical trials, resulting in a lack of evidence. OBJECTIVE: The aim of this study was to compare treatment and overall survival (OS) of patients aged ≥ 70 years with stage I–II pancreatic cancer in the EURECCA Pancreas Consortium. METHODS: This was an observational cohort study of the Belgian (BE), Dutch (NL), and Norwegian (NOR) cancer registries. The primary outcome was OS, while secondary outcomes were resection, 90-day mortality after resection, and (neo)adjuvant and palliative chemotherapy. RESULTS: In total, 3624 patients were included. Resection (BE: 50.2%; NL: 36.2%; NOR: 41.3%; p < 0.001), use of (neo)adjuvant chemotherapy (BE: 55.9%; NL: 41.9%; NOR: 13.8%; p < 0.001), palliative chemotherapy (BE: 39.5%; NL: 6.0%; NOR: 15.7%; p < 0.001), and 90-day mortality differed (BE: 11.7%; NL: 8.0%; NOR: 5.2%; p < 0.001). Furthermore, median OS in patients with (BE: 17.4; NL: 15.9; NOR: 25.4 months; p < 0.001) and without resection (BE: 7.0; NL: 3.9; NOR: 6.5 months; p < 0.001) also differed. CONCLUSIONS: Differences were observed in treatment and OS in patients aged ≥ 70 years with stage I–II pancreatic cancer, between the population-based cancer registries. Future studies should focus on selection criteria for (non)surgical treatment in older patients so that clinicians can tailor treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1245/s10434-020-08539-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7669775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-76697752020-11-17 Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium Groen, Jesse V. Douwes, Tom A. van Eycken, Elizabeth van der Geest, Lydia G. M. Johannesen, Tom B. Besselink, Marc G. Koerkamp, Bas Groot Wilmink, Johanna W. Bonsing, Bert A. Portielje, Johanna E. A. van de Velde, Cornelus J. H. Bastiaannet, Esther Mieog, J. Sven D. Ann Surg Oncol Pancreatic Tumors BACKGROUND: Elderly patients with pancreatic cancer are underrepresented in clinical trials, resulting in a lack of evidence. OBJECTIVE: The aim of this study was to compare treatment and overall survival (OS) of patients aged ≥ 70 years with stage I–II pancreatic cancer in the EURECCA Pancreas Consortium. METHODS: This was an observational cohort study of the Belgian (BE), Dutch (NL), and Norwegian (NOR) cancer registries. The primary outcome was OS, while secondary outcomes were resection, 90-day mortality after resection, and (neo)adjuvant and palliative chemotherapy. RESULTS: In total, 3624 patients were included. Resection (BE: 50.2%; NL: 36.2%; NOR: 41.3%; p < 0.001), use of (neo)adjuvant chemotherapy (BE: 55.9%; NL: 41.9%; NOR: 13.8%; p < 0.001), palliative chemotherapy (BE: 39.5%; NL: 6.0%; NOR: 15.7%; p < 0.001), and 90-day mortality differed (BE: 11.7%; NL: 8.0%; NOR: 5.2%; p < 0.001). Furthermore, median OS in patients with (BE: 17.4; NL: 15.9; NOR: 25.4 months; p < 0.001) and without resection (BE: 7.0; NL: 3.9; NOR: 6.5 months; p < 0.001) also differed. CONCLUSIONS: Differences were observed in treatment and OS in patients aged ≥ 70 years with stage I–II pancreatic cancer, between the population-based cancer registries. Future studies should focus on selection criteria for (non)surgical treatment in older patients so that clinicians can tailor treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1245/s10434-020-08539-x) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-05-09 2020 /pmc/articles/PMC7669775/ /pubmed/32388741 http://dx.doi.org/10.1245/s10434-020-08539-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Pancreatic Tumors Groen, Jesse V. Douwes, Tom A. van Eycken, Elizabeth van der Geest, Lydia G. M. Johannesen, Tom B. Besselink, Marc G. Koerkamp, Bas Groot Wilmink, Johanna W. Bonsing, Bert A. Portielje, Johanna E. A. van de Velde, Cornelus J. H. Bastiaannet, Esther Mieog, J. Sven D. Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title | Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title_full | Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title_fullStr | Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title_full_unstemmed | Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title_short | Treatment and Survival of Elderly Patients with Stage I–II Pancreatic Cancer: A Report of the EURECCA Pancreas Consortium |
title_sort | treatment and survival of elderly patients with stage i–ii pancreatic cancer: a report of the eurecca pancreas consortium |
topic | Pancreatic Tumors |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669775/ https://www.ncbi.nlm.nih.gov/pubmed/32388741 http://dx.doi.org/10.1245/s10434-020-08539-x |
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