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Craniofacial morphology in down syndrome: a systematic review and meta-analysis
The aim of this study was to evaluate the craniofacial cephalometric characteristics of individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic search was made in Pubmed, Embase, Lilacs, Scopus, Medline and Web of Science without imposing limitations on publication d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669844/ https://www.ncbi.nlm.nih.gov/pubmed/33199843 http://dx.doi.org/10.1038/s41598-020-76984-5 |
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author | Vicente, Ascensión Bravo-González, Luis-Alberto López-Romero, Ana Muñoz, Clara Serna Sánchez-Meca, Julio |
author_facet | Vicente, Ascensión Bravo-González, Luis-Alberto López-Romero, Ana Muñoz, Clara Serna Sánchez-Meca, Julio |
author_sort | Vicente, Ascensión |
collection | PubMed |
description | The aim of this study was to evaluate the craniofacial cephalometric characteristics of individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic search was made in Pubmed, Embase, Lilacs, Scopus, Medline and Web of Science without imposing limitations on publication date or language. Studies were selecting following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The PECO acronym was applied as follows: P (population), individuals with DS; E, (exposition) diagnosis of DS; C (comparison), individuals without DS; O (outcomes) craniofacial characteristics based on cephalometric measurements. Independent reviewers performed data extraction and assessed the methodological quality of the articles using the Newcastle–Ottawa Quality-Assessment-scale. Seven case–control studies were included in meta-analysis. Given the variability of the cephalometric measurements used, only those that had been reported in at least three or more works could be included. Anterior cranial base length (SN), posterior cranial base length (SBa), total cranial base length (BaN), effective length of the maxilla (CoA), sagittal relationship between subspinale and supramentale (ANB), anterior facial height (NMe), and posterior facial height (SGo) values were significantly lower in the DS population than among control subjects. No significant differences were found in sagittal position of subspinale relative to cranial base (SNA) and sagittal position of supramentale relative to cranial base (SNB). Summarizing, individuals with DS present a shorter and flatter cranial base than the general population, an upper jaw of reduced sagittal dimension, as well as a tendency toward prognatic profile, with the medium third of the face flattened and a reduced anterior and posterior facial heights. |
format | Online Article Text |
id | pubmed-7669844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76698442020-11-18 Craniofacial morphology in down syndrome: a systematic review and meta-analysis Vicente, Ascensión Bravo-González, Luis-Alberto López-Romero, Ana Muñoz, Clara Serna Sánchez-Meca, Julio Sci Rep Article The aim of this study was to evaluate the craniofacial cephalometric characteristics of individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic search was made in Pubmed, Embase, Lilacs, Scopus, Medline and Web of Science without imposing limitations on publication date or language. Studies were selecting following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The PECO acronym was applied as follows: P (population), individuals with DS; E, (exposition) diagnosis of DS; C (comparison), individuals without DS; O (outcomes) craniofacial characteristics based on cephalometric measurements. Independent reviewers performed data extraction and assessed the methodological quality of the articles using the Newcastle–Ottawa Quality-Assessment-scale. Seven case–control studies were included in meta-analysis. Given the variability of the cephalometric measurements used, only those that had been reported in at least three or more works could be included. Anterior cranial base length (SN), posterior cranial base length (SBa), total cranial base length (BaN), effective length of the maxilla (CoA), sagittal relationship between subspinale and supramentale (ANB), anterior facial height (NMe), and posterior facial height (SGo) values were significantly lower in the DS population than among control subjects. No significant differences were found in sagittal position of subspinale relative to cranial base (SNA) and sagittal position of supramentale relative to cranial base (SNB). Summarizing, individuals with DS present a shorter and flatter cranial base than the general population, an upper jaw of reduced sagittal dimension, as well as a tendency toward prognatic profile, with the medium third of the face flattened and a reduced anterior and posterior facial heights. Nature Publishing Group UK 2020-11-16 /pmc/articles/PMC7669844/ /pubmed/33199843 http://dx.doi.org/10.1038/s41598-020-76984-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Vicente, Ascensión Bravo-González, Luis-Alberto López-Romero, Ana Muñoz, Clara Serna Sánchez-Meca, Julio Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title | Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title_full | Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title_fullStr | Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title_full_unstemmed | Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title_short | Craniofacial morphology in down syndrome: a systematic review and meta-analysis |
title_sort | craniofacial morphology in down syndrome: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669844/ https://www.ncbi.nlm.nih.gov/pubmed/33199843 http://dx.doi.org/10.1038/s41598-020-76984-5 |
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