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Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives

Cancer is one of the main causes of mortality in the world. Many cancer cells produce ATP through high-level lactic acid fermentation catalyzed by lactate dehydrogenase (LDH), which converts pyruvic acid to lactic acid. LDH plays a dominant role in the Warburg effect, wherein aerobic glycolysis is f...

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Detalles Bibliográficos
Autores principales:	Annas, Dicky, Cheon, Se-Yun, Yusuf, Mohammad, Bae, Sung-Jin, Ha, Ki-Tae, Park, Kang Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669867/ https://www.ncbi.nlm.nih.gov/pubmed/33199724 http://dx.doi.org/10.1038/s41598-020-77056-4

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