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MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy

INTRODUCTION: Macrophage expressed gene 1 (MPEG1) is highly expressed in macrophages and other phagocytes. The gene encodes a bactericidal pore-forming protein, dubbed Perforin-2. Structural-, animal-, and cell-based studies have established that perforin-2 facilitates the destruction of phagocytose...

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Detalles Bibliográficos
Autores principales:	Merselis, Leidy C., Jiang, Shirley Y., Nelson, Stanley F., Lee, Hane, Prabaker, Kavitha K., Baker, Jennifer L., Munson, George P., Butte, Manish J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670069/ https://www.ncbi.nlm.nih.gov/pubmed/33224153 http://dx.doi.org/10.3389/fimmu.2020.601584

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