CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis

BACKGROUND: CXCL13 is a B and T lymphocyte chemokine that mediates neuroinflammation through its receptor CXCR5. This chemokine is highly expressed by motoneurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) SOD1G93A (mSOD1) mice during the disease, particularly in fast-progressing mice. Accordingly...

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Detalles Bibliográficos
Autores principales: Trolese, Maria Chiara, Mariani, Alessandro, Terao, Mineko, de Paola, Massimiliano, Fabbrizio, Paola, Sironi, Francesca, Kurosaki, Mami, Bonanno, Silvia, Marcuzzo, Silvia, Bernasconi, Pia, Trojsi, Francesca, Aronica, Eleonora, Bendotti, Caterina, Nardo, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670099/
https://www.ncbi.nlm.nih.gov/pubmed/33161233
http://dx.doi.org/10.1016/j.ebiom.2020.103097

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