Cargando…

Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging

INTRODUCTION: Myasthenia gravis (MG) is a relatively uncommon neuromuscular disease. The thymus plays an important role in the pathogenesis of MG, with 70% of patients presenting with thymic follicular hyperplasia and 20% presenting with thymoma. This study aimed to characterize magnetic resonance (...

Descripción completa

Detalles Bibliográficos
Autores principales: Tuan, Phung Anh, Duc, Nguyen Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670178/
https://www.ncbi.nlm.nih.gov/pubmed/33235546
http://dx.doi.org/10.5114/wo.2020.98861
_version_ 1783610687434522624
author Tuan, Phung Anh
Duc, Nguyen Minh
author_facet Tuan, Phung Anh
Duc, Nguyen Minh
author_sort Tuan, Phung Anh
collection PubMed
description INTRODUCTION: Myasthenia gravis (MG) is a relatively uncommon neuromuscular disease. The thymus plays an important role in the pathogenesis of MG, with 70% of patients presenting with thymic follicular hyperplasia and 20% presenting with thymoma. This study aimed to characterize magnetic resonance (MR) images of thymomas in patients with MG, associated with various stages and types. MATERIAL AND METHODS: A prospective study was performed in 46 MG patients with thymoma, who underwent surgery between August 2014 and September 2018, in Vietnam. Differences in MR imaging (MRI) images, according to type and stage, were assessed by the χ(2) test or Fisher’s exact test and Student’s t-test. A p-value < 0.05 was considered significant. RESULTS: The proportions of each type of thymomas found to be invasive were 28.6%, 61.1%, 66.7%, 90.9%, and 100%, for type A, AB, B1, B2, and B3 thymomas, respectively. Heterogeneous signal intensities on T1- and T2-weighted images, necrosis, and cysts were more commonly observed in high-risk thymomas than in low-risk thymomas. Non-invasive thymomas were more likely to display smooth margins than invasive thymomas (p < 0.05). Only 16.7% of invasive thymomas were detected in MR findings. CONCLUSIONS: Only a few characteristic MRI features could be used to differentiate thymomas by stage or type.
format Online
Article
Text
id pubmed-7670178
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-76701782020-11-23 Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging Tuan, Phung Anh Duc, Nguyen Minh Contemp Oncol (Pozn) Original Paper INTRODUCTION: Myasthenia gravis (MG) is a relatively uncommon neuromuscular disease. The thymus plays an important role in the pathogenesis of MG, with 70% of patients presenting with thymic follicular hyperplasia and 20% presenting with thymoma. This study aimed to characterize magnetic resonance (MR) images of thymomas in patients with MG, associated with various stages and types. MATERIAL AND METHODS: A prospective study was performed in 46 MG patients with thymoma, who underwent surgery between August 2014 and September 2018, in Vietnam. Differences in MR imaging (MRI) images, according to type and stage, were assessed by the χ(2) test or Fisher’s exact test and Student’s t-test. A p-value < 0.05 was considered significant. RESULTS: The proportions of each type of thymomas found to be invasive were 28.6%, 61.1%, 66.7%, 90.9%, and 100%, for type A, AB, B1, B2, and B3 thymomas, respectively. Heterogeneous signal intensities on T1- and T2-weighted images, necrosis, and cysts were more commonly observed in high-risk thymomas than in low-risk thymomas. Non-invasive thymomas were more likely to display smooth margins than invasive thymomas (p < 0.05). Only 16.7% of invasive thymomas were detected in MR findings. CONCLUSIONS: Only a few characteristic MRI features could be used to differentiate thymomas by stage or type. Termedia Publishing House 2020-09-17 2020 /pmc/articles/PMC7670178/ /pubmed/33235546 http://dx.doi.org/10.5114/wo.2020.98861 Text en Copyright © 2020 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Paper
Tuan, Phung Anh
Duc, Nguyen Minh
Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title_full Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title_fullStr Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title_full_unstemmed Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title_short Magnetic resonance imaging characteristics of thymoma in Vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
title_sort magnetic resonance imaging characteristics of thymoma in vietnamese patients with myasthenia gravis in relation to histopathological type and disease staging
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670178/
https://www.ncbi.nlm.nih.gov/pubmed/33235546
http://dx.doi.org/10.5114/wo.2020.98861
work_keys_str_mv AT tuanphunganh magneticresonanceimagingcharacteristicsofthymomainvietnamesepatientswithmyastheniagravisinrelationtohistopathologicaltypeanddiseasestaging
AT ducnguyenminh magneticresonanceimagingcharacteristicsofthymomainvietnamesepatientswithmyastheniagravisinrelationtohistopathologicaltypeanddiseasestaging