The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs

Transcriptional fidelity depends on accurate promoter selection and initiation from the correct sites. In yeast, H3K36me3-mediated recruitment of the Rpd3S HDAC complex to gene bodies suppresses spurious transcription initiation. Here we describe an equivalent pathway in metazoans. PWWP2A/B is an H3...

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Detalles Bibliográficos
Autores principales: Wei, Guifeng, Brockdorff, Neil, Zhang, Tianyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670215/
https://www.ncbi.nlm.nih.gov/pubmed/33235983
http://dx.doi.org/10.1016/j.isci.2020.101741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670215/
https://www.ncbi.nlm.nih.gov/pubmed/33235983
http://dx.doi.org/10.1016/j.isci.2020.101741

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