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Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia

BACKGROUND: Telfairia occidentalis (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hypoglycaemic hyperglycaemia. However, the mechanism...

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Autores principales: Salman, Toyin Mohammed, Alagbonsi, Isiaka Abdullateef, Sulaiman, Sheu Oluwadare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670218/
https://www.ncbi.nlm.nih.gov/pubmed/33235989
http://dx.doi.org/10.1016/j.metop.2020.100065
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author Salman, Toyin Mohammed
Alagbonsi, Isiaka Abdullateef
Sulaiman, Sheu Oluwadare
author_facet Salman, Toyin Mohammed
Alagbonsi, Isiaka Abdullateef
Sulaiman, Sheu Oluwadare
author_sort Salman, Toyin Mohammed
collection PubMed
description BACKGROUND: Telfairia occidentalis (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hypoglycaemic hyperglycaemia. However, the mechanism involved in the post-hypoglycaemic hyperglycaemia is still poorly understood. OBJECTIVE: This research was designed to determine the response of glucoregulatory hormones and enzymes to TO treatment. METHODS: Thirty-five male Wistar rats were divided into seven oral treatment groups (n = 5/group), which received either of 100 mg/kg or 200 mg/kg TO for 7-, 10- or 14 days. RESULTS: The 7-day treatment with TO significantly increased the levels of insulin, glucagon, and glucose-6-phosphatase (G6Pase) activity but decreased the levels of glucose, adrenaline, and glucokinase (GCK) activity. The 10-day treatment with 100 mg/kg TO increased glucose and decreased GCK activity while 200 mg/kg for the same duration increased glucose, insulin, GCK and G6Pase activities but reduced glucagon. The 14-day treatment with 100 mg/kg TO decreased glucose and glucagon but increased cortisol, while 200 mg/kg TO for same duration increased insulin, but reduced glucagon and GCK activity. CONCLUSION: The TO’s post-hypoglycaemic hyperglycaemia results from increased glucagon and G6Pase activity, and reduced GCK activity. Moreover, the glucagon response mainly depends on glucose rather than insulin.
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spelling pubmed-76702182020-11-23 Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia Salman, Toyin Mohammed Alagbonsi, Isiaka Abdullateef Sulaiman, Sheu Oluwadare Metabol Open Original Research Paper BACKGROUND: Telfairia occidentalis (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hypoglycaemic hyperglycaemia. However, the mechanism involved in the post-hypoglycaemic hyperglycaemia is still poorly understood. OBJECTIVE: This research was designed to determine the response of glucoregulatory hormones and enzymes to TO treatment. METHODS: Thirty-five male Wistar rats were divided into seven oral treatment groups (n = 5/group), which received either of 100 mg/kg or 200 mg/kg TO for 7-, 10- or 14 days. RESULTS: The 7-day treatment with TO significantly increased the levels of insulin, glucagon, and glucose-6-phosphatase (G6Pase) activity but decreased the levels of glucose, adrenaline, and glucokinase (GCK) activity. The 10-day treatment with 100 mg/kg TO increased glucose and decreased GCK activity while 200 mg/kg for the same duration increased glucose, insulin, GCK and G6Pase activities but reduced glucagon. The 14-day treatment with 100 mg/kg TO decreased glucose and glucagon but increased cortisol, while 200 mg/kg TO for same duration increased insulin, but reduced glucagon and GCK activity. CONCLUSION: The TO’s post-hypoglycaemic hyperglycaemia results from increased glucagon and G6Pase activity, and reduced GCK activity. Moreover, the glucagon response mainly depends on glucose rather than insulin. Elsevier 2020-11-05 /pmc/articles/PMC7670218/ /pubmed/33235989 http://dx.doi.org/10.1016/j.metop.2020.100065 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Paper
Salman, Toyin Mohammed
Alagbonsi, Isiaka Abdullateef
Sulaiman, Sheu Oluwadare
Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title_full Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title_fullStr Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title_full_unstemmed Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title_short Counter-regulatory responses to Telfairia occidentalis-induced hypoglycaemia
title_sort counter-regulatory responses to telfairia occidentalis-induced hypoglycaemia
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670218/
https://www.ncbi.nlm.nih.gov/pubmed/33235989
http://dx.doi.org/10.1016/j.metop.2020.100065
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