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Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report

Radiation-induced angiosarcoma (RIAS) after breast-conserving surgery is quite rare. Risk factors for RIAS have yet to be identified, due largely to the very low incidence of this disease. The etiologic mechanisms of RIAS are not understood, although some reports suggest that genome instability may...

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Autores principales: Ishizuka, Yumiko, Horimoto, Yoshiya, Onagi, Hiroko, Arakawa, Atsushi, Saito, Mitsue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670326/
https://www.ncbi.nlm.nih.gov/pubmed/33250743
http://dx.doi.org/10.1159/000510809
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author Ishizuka, Yumiko
Horimoto, Yoshiya
Onagi, Hiroko
Arakawa, Atsushi
Saito, Mitsue
author_facet Ishizuka, Yumiko
Horimoto, Yoshiya
Onagi, Hiroko
Arakawa, Atsushi
Saito, Mitsue
author_sort Ishizuka, Yumiko
collection PubMed
description Radiation-induced angiosarcoma (RIAS) after breast-conserving surgery is quite rare. Risk factors for RIAS have yet to be identified, due largely to the very low incidence of this disease. The etiologic mechanisms of RIAS are not understood, although some reports suggest that genome instability may contribute to RIAS development. An 81-year-old Japanese woman presented to our hospital after developing multiple dark purple nodules on her left breast. She had undergone breast-conserving surgery for left breast cancer and adjuvant radiotherapy for the conserved breast 9 years earlier. Punch biopsy of one of the dark purple nodules was performed and the pathological diagnosis was angiosarcoma. She underwent total mastectomy with an adequate margin, and skin collected from her left thigh was grafted onto the site. Pathologically, the surgical margin was negative. The tumor was negative for microsatellite instability (MSI). Considering her age, she has remained under careful observation with neither systemic treatment nor adjuvant radiation. The only standard therapy for RIAS currently available is complete resection. Hence, early detection is crucial to obtain an adequate margin, followed by careful observation after breast-conserving surgery. It is also essential to reveal the tumor etiology, and for that purpose, we believe that the MSI status may be beneficial for the further investigation of RIAS.
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spelling pubmed-76703262020-11-27 Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report Ishizuka, Yumiko Horimoto, Yoshiya Onagi, Hiroko Arakawa, Atsushi Saito, Mitsue Case Rep Oncol Case Report Radiation-induced angiosarcoma (RIAS) after breast-conserving surgery is quite rare. Risk factors for RIAS have yet to be identified, due largely to the very low incidence of this disease. The etiologic mechanisms of RIAS are not understood, although some reports suggest that genome instability may contribute to RIAS development. An 81-year-old Japanese woman presented to our hospital after developing multiple dark purple nodules on her left breast. She had undergone breast-conserving surgery for left breast cancer and adjuvant radiotherapy for the conserved breast 9 years earlier. Punch biopsy of one of the dark purple nodules was performed and the pathological diagnosis was angiosarcoma. She underwent total mastectomy with an adequate margin, and skin collected from her left thigh was grafted onto the site. Pathologically, the surgical margin was negative. The tumor was negative for microsatellite instability (MSI). Considering her age, she has remained under careful observation with neither systemic treatment nor adjuvant radiation. The only standard therapy for RIAS currently available is complete resection. Hence, early detection is crucial to obtain an adequate margin, followed by careful observation after breast-conserving surgery. It is also essential to reveal the tumor etiology, and for that purpose, we believe that the MSI status may be beneficial for the further investigation of RIAS. S. Karger AG 2020-10-15 /pmc/articles/PMC7670326/ /pubmed/33250743 http://dx.doi.org/10.1159/000510809 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Ishizuka, Yumiko
Horimoto, Yoshiya
Onagi, Hiroko
Arakawa, Atsushi
Saito, Mitsue
Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title_full Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title_fullStr Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title_full_unstemmed Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title_short Microsatellite-Stable Radiation-Induced Angiosarcoma after Breast-Conserving Surgery: A Case Report
title_sort microsatellite-stable radiation-induced angiosarcoma after breast-conserving surgery: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670326/
https://www.ncbi.nlm.nih.gov/pubmed/33250743
http://dx.doi.org/10.1159/000510809
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