Critical roles of FAM134B in ER-phagy and diseases

FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions...

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Autores principales: Mo, Jie, Chen, Jin, Zhang, Bixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670425/
https://www.ncbi.nlm.nih.gov/pubmed/33199694
http://dx.doi.org/10.1038/s41419-020-03195-1
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author Mo, Jie
Chen, Jin
Zhang, Bixiang
author_facet Mo, Jie
Chen, Jin
Zhang, Bixiang
author_sort Mo, Jie
collection PubMed
description FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. This review describes the biological functions of FAM134B, focusing on its role in ER-phagy. In addition, we summarize the diseases in which it is involved and review the underlying mechanisms.
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spelling pubmed-76704252020-11-20 Critical roles of FAM134B in ER-phagy and diseases Mo, Jie Chen, Jin Zhang, Bixiang Cell Death Dis Review Article FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. This review describes the biological functions of FAM134B, focusing on its role in ER-phagy. In addition, we summarize the diseases in which it is involved and review the underlying mechanisms. Nature Publishing Group UK 2020-11-16 /pmc/articles/PMC7670425/ /pubmed/33199694 http://dx.doi.org/10.1038/s41419-020-03195-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Mo, Jie
Chen, Jin
Zhang, Bixiang
Critical roles of FAM134B in ER-phagy and diseases
title Critical roles of FAM134B in ER-phagy and diseases
title_full Critical roles of FAM134B in ER-phagy and diseases
title_fullStr Critical roles of FAM134B in ER-phagy and diseases
title_full_unstemmed Critical roles of FAM134B in ER-phagy and diseases
title_short Critical roles of FAM134B in ER-phagy and diseases
title_sort critical roles of fam134b in er-phagy and diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670425/
https://www.ncbi.nlm.nih.gov/pubmed/33199694
http://dx.doi.org/10.1038/s41419-020-03195-1
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