Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress

BACKGROUND: The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology of manganese (Mn)-induced neurotoxicity. Sodium para-aminosalicylic acid (PAS-Na) has a positive effect on the treatment of manganism. However, the...

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Detalles Bibliográficos
Autores principales: Peng, Dongjie, Li, Junyan, Deng, Yue, Zhu, Xiaojuan, Zhao, Lin, Zhang, Yuwen, Li, Zhaocong, Ou, Shiyan, Li, Shaojun, Jiang, Yueming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670624/
https://www.ncbi.nlm.nih.gov/pubmed/33203418
http://dx.doi.org/10.1186/s12974-020-02018-6

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