Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma

BACKGROUND: SIRT6 has diverse roles in cells, and the role of SIRT6 in tumorigenesis is controversial. Considering the role of SIRT6 as an inducer of DNA damage repair, it might be involved in resistance to anti-cancer therapy. METHODS: We evaluated the prognostic significance of SIRT6 in 37 osteosa...

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Detalles Bibliográficos
Autores principales: Zhang, Zhongkai, Ha, Sang Hoon, Moon, Young Jae, Hussein, Usama Khamis, Song, Yiping, Kim, Kyoung Min, Park, See-Hyoung, Park, Ho Sung, Park, Byung-Hyun, Ahn, Ae-Ri, Lee, Sang-A, Ahn, Su Jin, Kim, Jung Ryul, Jang, Kyu Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670730/
https://www.ncbi.nlm.nih.gov/pubmed/33198792
http://dx.doi.org/10.1186/s13046-020-01759-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670730/
https://www.ncbi.nlm.nih.gov/pubmed/33198792
http://dx.doi.org/10.1186/s13046-020-01759-9

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