HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region

INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by...

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Detalles Bibliográficos
Autores principales: Pontes, Gemilson Soares, Ribeiro, Hygor Halyson Figueiredo, Toro, Diana Mota, de Moura, José Pereira, Souza, Victor, de Almeida, Maria Edilene Martins, do Nascimento, Valdinete Alves, da Costa, Cristovão Alves, Naveca, Felipe Gomes, Santos, Mike, Vallinoto, Antonio Carlos Rosário
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670738/
https://www.ncbi.nlm.nih.gov/pubmed/33206874
http://dx.doi.org/10.1590/0037-8682-0066-2020
Descripción
Sumario:INTRODUCTION: We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil. METHODS: Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region. RESULTS: A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype. CONCLUSIONS: This study describes the first known occurrence of HTLV-2c in the urban area of Brazil’s western Amazon region.

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