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Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Medicina Tropical - SBMT
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670749/ https://www.ncbi.nlm.nih.gov/pubmed/33206871 http://dx.doi.org/10.1590/0037-8682-0499-2019 |
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author | de Sousa, Ivanildo Pedro Machado, Raiana Scerni Burlandy, Fernanda Marcicano da Silva, Edson Elias |
author_facet | de Sousa, Ivanildo Pedro Machado, Raiana Scerni Burlandy, Fernanda Marcicano da Silva, Edson Elias |
author_sort | de Sousa, Ivanildo Pedro |
collection | PubMed |
description | Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections. |
format | Online Article Text |
id | pubmed-7670749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade Brasileira de Medicina Tropical - SBMT |
record_format | MEDLINE/PubMed |
spelling | pubmed-76707492020-11-18 Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 de Sousa, Ivanildo Pedro Machado, Raiana Scerni Burlandy, Fernanda Marcicano da Silva, Edson Elias Rev Soc Bras Med Trop Case Report Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections. Sociedade Brasileira de Medicina Tropical - SBMT 2020-11-13 /pmc/articles/PMC7670749/ /pubmed/33206871 http://dx.doi.org/10.1590/0037-8682-0499-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Case Report de Sousa, Ivanildo Pedro Machado, Raiana Scerni Burlandy, Fernanda Marcicano da Silva, Edson Elias Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title | Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title_full | Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title_fullStr | Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title_full_unstemmed | Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title_short | Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 |
title_sort | detection and characterization of a coxsackievirus b2 strain associated with acute meningoencephalitis, brazil, 2018 |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670749/ https://www.ncbi.nlm.nih.gov/pubmed/33206871 http://dx.doi.org/10.1590/0037-8682-0499-2019 |
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