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Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018

Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture a...

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Autores principales: de Sousa, Ivanildo Pedro, Machado, Raiana Scerni, Burlandy, Fernanda Marcicano, da Silva, Edson Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670749/
https://www.ncbi.nlm.nih.gov/pubmed/33206871
http://dx.doi.org/10.1590/0037-8682-0499-2019
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author de Sousa, Ivanildo Pedro
Machado, Raiana Scerni
Burlandy, Fernanda Marcicano
da Silva, Edson Elias
author_facet de Sousa, Ivanildo Pedro
Machado, Raiana Scerni
Burlandy, Fernanda Marcicano
da Silva, Edson Elias
author_sort de Sousa, Ivanildo Pedro
collection PubMed
description Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections.
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spelling pubmed-76707492020-11-18 Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018 de Sousa, Ivanildo Pedro Machado, Raiana Scerni Burlandy, Fernanda Marcicano da Silva, Edson Elias Rev Soc Bras Med Trop Case Report Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections. Sociedade Brasileira de Medicina Tropical - SBMT 2020-11-13 /pmc/articles/PMC7670749/ /pubmed/33206871 http://dx.doi.org/10.1590/0037-8682-0499-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Case Report
de Sousa, Ivanildo Pedro
Machado, Raiana Scerni
Burlandy, Fernanda Marcicano
da Silva, Edson Elias
Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title_full Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title_fullStr Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title_full_unstemmed Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title_short Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018
title_sort detection and characterization of a coxsackievirus b2 strain associated with acute meningoencephalitis, brazil, 2018
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670749/
https://www.ncbi.nlm.nih.gov/pubmed/33206871
http://dx.doi.org/10.1590/0037-8682-0499-2019
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