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Mediation model of comorbid anxiety disorders in late-life depression
BACKGROUND: A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. METHODS: Participants included 190 elderly Thais (73.2%...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670777/ https://www.ncbi.nlm.nih.gov/pubmed/33292322 http://dx.doi.org/10.1186/s12991-020-00313-3 |
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author | Suradom, Chawisa Wongpakaran, Nahathai Wongpakaran, Tinakon Lerttrakarnnon, Peerasak Jiraniramai, Surin Taemeeyapradit, Unchulee Lertkachatarn, Surang Arunpongpaisal, Suwanna Kuntawong, Pimolpun |
author_facet | Suradom, Chawisa Wongpakaran, Nahathai Wongpakaran, Tinakon Lerttrakarnnon, Peerasak Jiraniramai, Surin Taemeeyapradit, Unchulee Lertkachatarn, Surang Arunpongpaisal, Suwanna Kuntawong, Pimolpun |
author_sort | Suradom, Chawisa |
collection | PubMed |
description | BACKGROUND: A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. METHODS: Participants included 190 elderly Thais (73.2% female, with a mean age of 68.39 ± 6.74 years) with depressive disorders, diagnosed according to DSM-IV Diagnosis Axis I disorders assessed by Mini-International Neuropsychiatric Interview. Demographic data, medical and psychiatric history, family psychiatric history, past depression, family history of depression, Neuroticism Inventory and 7-Item Hamilton Depression Rating Scale (HAMD-7) were analyzed for path analysis using Structural Equation Model framework. The bootstrapping method was used for testing indirect effects. RESULTS: Being female was associated with comorbid anxiety disorders with an indirect effect (β = − 0.032, P = 0.018) through neuroticism, depression severity, history and family history of depression. Family history of depression had no effect on comorbidity (P = 0.090). Neuroticism had an indirect effect on comorbid anxiety disorders (β = 0.075, P = 0.019) via depression severity as reflected by HAMD-7 score (β = 0.412, P = < 0.001). Total variance explained from this model was 11%. This model had good-fit index with Chi-square > 0.05, CFI and TLI > 0.95 and RMSEA < 0.06. CONCLUSION: Neuroticism mediates the effect of relationship between sex, family history and history of depressive disorders and comorbid anxiety disorders in LLD. Moreover, depression severity is a mediator for neuroticism and comorbid anxiety disorders. Longitudinal studies are warranted to indicate the importance of effective treatment of depression to lower the risk of developing comorbid anxiety disorders among depressed elderly. |
format | Online Article Text |
id | pubmed-7670777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76707772020-11-18 Mediation model of comorbid anxiety disorders in late-life depression Suradom, Chawisa Wongpakaran, Nahathai Wongpakaran, Tinakon Lerttrakarnnon, Peerasak Jiraniramai, Surin Taemeeyapradit, Unchulee Lertkachatarn, Surang Arunpongpaisal, Suwanna Kuntawong, Pimolpun Ann Gen Psychiatry Primary Research BACKGROUND: A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. METHODS: Participants included 190 elderly Thais (73.2% female, with a mean age of 68.39 ± 6.74 years) with depressive disorders, diagnosed according to DSM-IV Diagnosis Axis I disorders assessed by Mini-International Neuropsychiatric Interview. Demographic data, medical and psychiatric history, family psychiatric history, past depression, family history of depression, Neuroticism Inventory and 7-Item Hamilton Depression Rating Scale (HAMD-7) were analyzed for path analysis using Structural Equation Model framework. The bootstrapping method was used for testing indirect effects. RESULTS: Being female was associated with comorbid anxiety disorders with an indirect effect (β = − 0.032, P = 0.018) through neuroticism, depression severity, history and family history of depression. Family history of depression had no effect on comorbidity (P = 0.090). Neuroticism had an indirect effect on comorbid anxiety disorders (β = 0.075, P = 0.019) via depression severity as reflected by HAMD-7 score (β = 0.412, P = < 0.001). Total variance explained from this model was 11%. This model had good-fit index with Chi-square > 0.05, CFI and TLI > 0.95 and RMSEA < 0.06. CONCLUSION: Neuroticism mediates the effect of relationship between sex, family history and history of depressive disorders and comorbid anxiety disorders in LLD. Moreover, depression severity is a mediator for neuroticism and comorbid anxiety disorders. Longitudinal studies are warranted to indicate the importance of effective treatment of depression to lower the risk of developing comorbid anxiety disorders among depressed elderly. BioMed Central 2020-11-17 /pmc/articles/PMC7670777/ /pubmed/33292322 http://dx.doi.org/10.1186/s12991-020-00313-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Primary Research Suradom, Chawisa Wongpakaran, Nahathai Wongpakaran, Tinakon Lerttrakarnnon, Peerasak Jiraniramai, Surin Taemeeyapradit, Unchulee Lertkachatarn, Surang Arunpongpaisal, Suwanna Kuntawong, Pimolpun Mediation model of comorbid anxiety disorders in late-life depression |
title | Mediation model of comorbid anxiety disorders in late-life depression |
title_full | Mediation model of comorbid anxiety disorders in late-life depression |
title_fullStr | Mediation model of comorbid anxiety disorders in late-life depression |
title_full_unstemmed | Mediation model of comorbid anxiety disorders in late-life depression |
title_short | Mediation model of comorbid anxiety disorders in late-life depression |
title_sort | mediation model of comorbid anxiety disorders in late-life depression |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670777/ https://www.ncbi.nlm.nih.gov/pubmed/33292322 http://dx.doi.org/10.1186/s12991-020-00313-3 |
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