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Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study

BACKGROUND: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japane...

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Autores principales: Furukawa, Shinya, Yagi, Sen, Shiraishi, Kana, Mori, Kenichirou, Ninomiya, Tomoyuki, Kawasaki, Keitarou, Mizukami, Yuji, Suzuki, Seiyuu, Uraoka, Masayoshi, Shibata, Naozumi, Nakamura, Sanae, Imamine, Satoshi, Murakami, Hidehiro, Ohashi, Katsuhisa, Torisu, Masamoto, Hasebe, Aki, Yano, Harumi, Murakami, Masato, Takeshita, Eiji, Ikeda, Yoshio, Hiasa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670794/
https://www.ncbi.nlm.nih.gov/pubmed/33198664
http://dx.doi.org/10.1186/s12876-020-01538-y
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author Furukawa, Shinya
Yagi, Sen
Shiraishi, Kana
Mori, Kenichirou
Ninomiya, Tomoyuki
Kawasaki, Keitarou
Mizukami, Yuji
Suzuki, Seiyuu
Uraoka, Masayoshi
Shibata, Naozumi
Nakamura, Sanae
Imamine, Satoshi
Murakami, Hidehiro
Ohashi, Katsuhisa
Torisu, Masamoto
Hasebe, Aki
Yano, Harumi
Murakami, Masato
Takeshita, Eiji
Ikeda, Yoshio
Hiasa, Yoichi
author_facet Furukawa, Shinya
Yagi, Sen
Shiraishi, Kana
Mori, Kenichirou
Ninomiya, Tomoyuki
Kawasaki, Keitarou
Mizukami, Yuji
Suzuki, Seiyuu
Uraoka, Masayoshi
Shibata, Naozumi
Nakamura, Sanae
Imamine, Satoshi
Murakami, Hidehiro
Ohashi, Katsuhisa
Torisu, Masamoto
Hasebe, Aki
Yano, Harumi
Murakami, Masato
Takeshita, Eiji
Ikeda, Yoshio
Hiasa, Yoichi
author_sort Furukawa, Shinya
collection PubMed
description BACKGROUND: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. METHODS: The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. RESULTS: The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors. CONCLUSIONS: Among patients with UC, platelet count was independently inversely associated with MH
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spelling pubmed-76707942020-11-18 Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study Furukawa, Shinya Yagi, Sen Shiraishi, Kana Mori, Kenichirou Ninomiya, Tomoyuki Kawasaki, Keitarou Mizukami, Yuji Suzuki, Seiyuu Uraoka, Masayoshi Shibata, Naozumi Nakamura, Sanae Imamine, Satoshi Murakami, Hidehiro Ohashi, Katsuhisa Torisu, Masamoto Hasebe, Aki Yano, Harumi Murakami, Masato Takeshita, Eiji Ikeda, Yoshio Hiasa, Yoichi BMC Gastroenterol Research Article BACKGROUND: Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. METHODS: The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0–1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. RESULTS: The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19–0.810], very high: OR 0.37 [95%CI 0.17–0.77], p for trend = 0.034). Similarly, moderate, high, and very high were independently inversely associated with MH (moderate: OR 0.37 [95% CI 0.18–0.73], high: OR 0.41 [95% CI 0.19–0.83], and very high: OR 0.45 [95% CI 0.21–0.94], p for trend = 0.033) after adjustment for confounding factors. CONCLUSIONS: Among patients with UC, platelet count was independently inversely associated with MH BioMed Central 2020-11-16 /pmc/articles/PMC7670794/ /pubmed/33198664 http://dx.doi.org/10.1186/s12876-020-01538-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Furukawa, Shinya
Yagi, Sen
Shiraishi, Kana
Mori, Kenichirou
Ninomiya, Tomoyuki
Kawasaki, Keitarou
Mizukami, Yuji
Suzuki, Seiyuu
Uraoka, Masayoshi
Shibata, Naozumi
Nakamura, Sanae
Imamine, Satoshi
Murakami, Hidehiro
Ohashi, Katsuhisa
Torisu, Masamoto
Hasebe, Aki
Yano, Harumi
Murakami, Masato
Takeshita, Eiji
Ikeda, Yoshio
Hiasa, Yoichi
Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title_full Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title_fullStr Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title_full_unstemmed Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title_short Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study
title_sort association between platelet count and mucosal healing in japanese patients with ulcerative colitis: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670794/
https://www.ncbi.nlm.nih.gov/pubmed/33198664
http://dx.doi.org/10.1186/s12876-020-01538-y
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