Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the human ACE2 receptor and to facilitate virus entry, which can occur through low-pH-endosomal pathways. To understand how ACE2 binding and low pH affect spike conformation, we determined cryo-electron microscopy structur...

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Detalles Bibliográficos
Autores principales: Zhou, Tongqing, Tsybovsky, Yaroslav, Gorman, Jason, Rapp, Micah, Cerutti, Gabriele, Chuang, Gwo-Yu, Katsamba, Phinikoula S., Sampson, Jared M., Schön, Arne, Bimela, Jude, Boyington, Jeffrey C., Nazzari, Alexandra, Olia, Adam S., Shi, Wei, Sastry, Mallika, Stephens, Tyler, Stuckey, Jonathan, Teng, I-Ting, Wang, Pengfei, Wang, Shuishu, Zhang, Baoshan, Friesner, Richard A., Ho, David D., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670890/
https://www.ncbi.nlm.nih.gov/pubmed/33271067
http://dx.doi.org/10.1016/j.chom.2020.11.004

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