Exploring role of 5hmC as potential marker of chemoresistance

Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings s...

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Detalles Bibliográficos
Autores principales: Kharat, Suhas S., Sharan, Shyam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671001/
https://www.ncbi.nlm.nih.gov/pubmed/33235920
http://dx.doi.org/10.1080/23723556.2020.1827904
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author Kharat, Suhas S.
Sharan, Shyam K.
author_facet Kharat, Suhas S.
Sharan, Shyam K.
author_sort Kharat, Suhas S.
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description Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified a novel role for 5-hydroxymethycytosine (5hmC), an epigenetic mark on the DNA, in maintaining the integrity of stalled replication forks and its impact on genomic stability and chemoresistance.
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spelling pubmed-76710012020-11-23 Exploring role of 5hmC as potential marker of chemoresistance Kharat, Suhas S. Sharan, Shyam K. Mol Cell Oncol Commentary Chemoresistance remains to be a common and significant hurdle with all chemotherapies. Tumors gain resistance by acquiring additional mutations. Some of the chemoresistance mechanisms are known and can be tackled. However, the majority of chemoresistance mechanisms are unknown. Our recent findings shed light on one such unknown mechanism. We identified a novel role for 5-hydroxymethycytosine (5hmC), an epigenetic mark on the DNA, in maintaining the integrity of stalled replication forks and its impact on genomic stability and chemoresistance. Taylor & Francis 2020-10-22 /pmc/articles/PMC7671001/ /pubmed/33235920 http://dx.doi.org/10.1080/23723556.2020.1827904 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Kharat, Suhas S.
Sharan, Shyam K.
Exploring role of 5hmC as potential marker of chemoresistance
title Exploring role of 5hmC as potential marker of chemoresistance
title_full Exploring role of 5hmC as potential marker of chemoresistance
title_fullStr Exploring role of 5hmC as potential marker of chemoresistance
title_full_unstemmed Exploring role of 5hmC as potential marker of chemoresistance
title_short Exploring role of 5hmC as potential marker of chemoresistance
title_sort exploring role of 5hmc as potential marker of chemoresistance
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671001/
https://www.ncbi.nlm.nih.gov/pubmed/33235920
http://dx.doi.org/10.1080/23723556.2020.1827904
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