Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells

p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function o...

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Detalles Bibliográficos
Autores principales: Azazmeh, Narmen, Ben-Porath, Ittai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671025/
https://www.ncbi.nlm.nih.gov/pubmed/33235916
http://dx.doi.org/10.1080/23723556.2020.1819752
Descripción
Sumario:p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16(INK4a) in early epidermal lesions, which could potentially be targeted by senolytic therapy.

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