Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells

p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function o...

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Autores principales: Azazmeh, Narmen, Ben-Porath, Ittai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671025/
https://www.ncbi.nlm.nih.gov/pubmed/33235916
http://dx.doi.org/10.1080/23723556.2020.1819752
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author Azazmeh, Narmen
Ben-Porath, Ittai
author_facet Azazmeh, Narmen
Ben-Porath, Ittai
author_sort Azazmeh, Narmen
collection PubMed
description p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16(INK4a) in early epidermal lesions, which could potentially be targeted by senolytic therapy.
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spelling pubmed-76710252020-11-23 Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells Azazmeh, Narmen Ben-Porath, Ittai Mol Cell Oncol Author’s Views p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16(INK4a) in early epidermal lesions, which could potentially be targeted by senolytic therapy. Taylor & Francis 2020-09-25 /pmc/articles/PMC7671025/ /pubmed/33235916 http://dx.doi.org/10.1080/23723556.2020.1819752 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Azazmeh, Narmen
Ben-Porath, Ittai
Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title_full Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title_fullStr Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title_full_unstemmed Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title_short Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
title_sort stimulation of epidermal hyperplasia and tumorigenesis by resident p16(ink4a)-expressing cells
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671025/
https://www.ncbi.nlm.nih.gov/pubmed/33235916
http://dx.doi.org/10.1080/23723556.2020.1819752
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