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Stimulation of epidermal hyperplasia and tumorigenesis by resident p16(INK4a)-expressing cells
p16(INK4a) (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16(INK4a) in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671025/ https://www.ncbi.nlm.nih.gov/pubmed/33235916 http://dx.doi.org/10.1080/23723556.2020.1819752 |