DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy

We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Xiang, Geng, Feng, Guo, Deliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671038/
https://www.ncbi.nlm.nih.gov/pubmed/33235909
http://dx.doi.org/10.1080/23723556.2020.1805257
_version_ 1783610852642914304
author Cheng, Xiang
Geng, Feng
Guo, Deliang
author_facet Cheng, Xiang
Geng, Feng
Guo, Deliang
author_sort Cheng, Xiang
collection PubMed
description We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensive oxidative stress, indicating that DGAT1 could be a promising target for cancer therapy.
format Online
Article
Text
id pubmed-7671038
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-76710382020-11-23 DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy Cheng, Xiang Geng, Feng Guo, Deliang Mol Cell Oncol Author’s Views We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensive oxidative stress, indicating that DGAT1 could be a promising target for cancer therapy. Taylor & Francis 2020-09-08 /pmc/articles/PMC7671038/ /pubmed/33235909 http://dx.doi.org/10.1080/23723556.2020.1805257 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Cheng, Xiang
Geng, Feng
Guo, Deliang
DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title_full DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title_fullStr DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title_full_unstemmed DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title_short DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
title_sort dgat1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671038/
https://www.ncbi.nlm.nih.gov/pubmed/33235909
http://dx.doi.org/10.1080/23723556.2020.1805257
work_keys_str_mv AT chengxiang dgat1protectstumorfromlipotoxicityemergingasapromisingmetabolictargetforcancertherapy
AT gengfeng dgat1protectstumorfromlipotoxicityemergingasapromisingmetabolictargetforcancertherapy
AT guodeliang dgat1protectstumorfromlipotoxicityemergingasapromisingmetabolictargetforcancertherapy

Ejemplares similares