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DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensiv...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671038/ https://www.ncbi.nlm.nih.gov/pubmed/33235909 http://dx.doi.org/10.1080/23723556.2020.1805257 |