Regulation of tumorigenic splicing by protein condensates with specific biophysical properties

The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and...

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Detalles Bibliográficos
Autores principales: Li, Wei, Jiang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671046/
https://www.ncbi.nlm.nih.gov/pubmed/33235917
http://dx.doi.org/10.1080/23723556.2020.1819753
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author Li, Wei
Jiang, Hao
author_facet Li, Wei
Jiang, Hao
author_sort Li, Wei
collection PubMed
description The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and that perturbing the biophysical properties of the condensates impairs its activity in regulating splicing and tumorigenesis.
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spelling pubmed-76710462020-11-23 Regulation of tumorigenic splicing by protein condensates with specific biophysical properties Li, Wei Jiang, Hao Mol Cell Oncol Author’s Views The role of biophysical properties of protein condensates in regulating gene expression and tumorigenesis remains unclear. We recently discovered that A-kinase anchoring protein 8 (AKAP8, also known as AKAP95), a RNA splicing regulator, supports tumorigenesis by forming liquid-like condensates, and that perturbing the biophysical properties of the condensates impairs its activity in regulating splicing and tumorigenesis. Taylor & Francis 2020-10-10 /pmc/articles/PMC7671046/ /pubmed/33235917 http://dx.doi.org/10.1080/23723556.2020.1819753 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Li, Wei
Jiang, Hao
Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title_full Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title_fullStr Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title_full_unstemmed Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title_short Regulation of tumorigenic splicing by protein condensates with specific biophysical properties
title_sort regulation of tumorigenic splicing by protein condensates with specific biophysical properties
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671046/
https://www.ncbi.nlm.nih.gov/pubmed/33235917
http://dx.doi.org/10.1080/23723556.2020.1819753
work_keys_str_mv AT liwei regulationoftumorigenicsplicingbyproteincondensateswithspecificbiophysicalproperties
AT jianghao regulationoftumorigenicsplicingbyproteincondensateswithspecificbiophysicalproperties

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