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Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma
Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma. Because many glioblastoma oncogenic drivers activate p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671052/ https://www.ncbi.nlm.nih.gov/pubmed/33235923 http://dx.doi.org/10.1080/23723556.2020.1834902 |