p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis

Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic de...

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Detalles Bibliográficos
Autores principales: Cain, Jason E., Watkins, D. Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671054/
https://www.ncbi.nlm.nih.gov/pubmed/33235907
http://dx.doi.org/10.1080/23723556.2020.1805095
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author Cain, Jason E.
Watkins, D. Neil
author_facet Cain, Jason E.
Watkins, D. Neil
author_sort Cain, Jason E.
collection PubMed
description Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic degradation of primary cilia.
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spelling pubmed-76710542020-11-23 p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis Cain, Jason E. Watkins, D. Neil Mol Cell Oncol Author’s Views Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic degradation of primary cilia. Taylor & Francis 2020-09-08 /pmc/articles/PMC7671054/ /pubmed/33235907 http://dx.doi.org/10.1080/23723556.2020.1805095 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Cain, Jason E.
Watkins, D. Neil
p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title_full p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title_fullStr p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title_full_unstemmed p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title_short p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
title_sort p53 and rb1 regulate hedgehog responsiveness via autophagy-mediated ciliogenesis
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671054/
https://www.ncbi.nlm.nih.gov/pubmed/33235907
http://dx.doi.org/10.1080/23723556.2020.1805095
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