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p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic de...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671054/ https://www.ncbi.nlm.nih.gov/pubmed/33235907 http://dx.doi.org/10.1080/23723556.2020.1805095 |