RT-QuIC detection of tauopathies using full-length tau substrates

Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfold...

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Detalles Bibliográficos
Autores principales: Tennant, Joanne M., Henderson, Davin M., Wisniewski, Thomas M., Hoover, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671068/
https://www.ncbi.nlm.nih.gov/pubmed/33171070
http://dx.doi.org/10.1080/19336896.2020.1832946
Descripción
Sumario:Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for neurodegenerative disease. Here we use full-length recombinant tau substrates to detect tau seeding activity in Alzheimer’s disease and other human tauopathies.

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