RT-QuIC detection of tauopathies using full-length tau substrates

Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfold...

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Autores principales: Tennant, Joanne M., Henderson, Davin M., Wisniewski, Thomas M., Hoover, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671068/
https://www.ncbi.nlm.nih.gov/pubmed/33171070
http://dx.doi.org/10.1080/19336896.2020.1832946
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author Tennant, Joanne M.
Henderson, Davin M.
Wisniewski, Thomas M.
Hoover, Edward A.
author_facet Tennant, Joanne M.
Henderson, Davin M.
Wisniewski, Thomas M.
Hoover, Edward A.
author_sort Tennant, Joanne M.
collection PubMed
description Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for neurodegenerative disease. Here we use full-length recombinant tau substrates to detect tau seeding activity in Alzheimer’s disease and other human tauopathies.
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spelling pubmed-76710682020-11-23 RT-QuIC detection of tauopathies using full-length tau substrates Tennant, Joanne M. Henderson, Davin M. Wisniewski, Thomas M. Hoover, Edward A. Prion Research Paper Early detection and diagnosis of neurodegenerative diseases has been hampered by the lack of sensitive testing. Real-time quaking induced conversion (RT-QuIC) has been used for the early and sensitive detection of prion-induced neurologic disease, and has more recently been adapted to detect misfolded alpha-synuclein and tau as biomarkers for neurodegenerative disease. Here we use full-length recombinant tau substrates to detect tau seeding activity in Alzheimer’s disease and other human tauopathies. Taylor & Francis 2020-11-10 /pmc/articles/PMC7671068/ /pubmed/33171070 http://dx.doi.org/10.1080/19336896.2020.1832946 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Tennant, Joanne M.
Henderson, Davin M.
Wisniewski, Thomas M.
Hoover, Edward A.
RT-QuIC detection of tauopathies using full-length tau substrates
title RT-QuIC detection of tauopathies using full-length tau substrates
title_full RT-QuIC detection of tauopathies using full-length tau substrates
title_fullStr RT-QuIC detection of tauopathies using full-length tau substrates
title_full_unstemmed RT-QuIC detection of tauopathies using full-length tau substrates
title_short RT-QuIC detection of tauopathies using full-length tau substrates
title_sort rt-quic detection of tauopathies using full-length tau substrates
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671068/
https://www.ncbi.nlm.nih.gov/pubmed/33171070
http://dx.doi.org/10.1080/19336896.2020.1832946
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