RSK2 and ERα comrades-in-arms in homeostasis and transformation

The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity t...

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Detalles Bibliográficos
Autores principales: Ludwik, Katarzyna A., Lannigan, Deborah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671069/
https://www.ncbi.nlm.nih.gov/pubmed/33235919
http://dx.doi.org/10.1080/23723556.2020.1825916
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author Ludwik, Katarzyna A.
Lannigan, Deborah A.
author_facet Ludwik, Katarzyna A.
Lannigan, Deborah A.
author_sort Ludwik, Katarzyna A.
collection PubMed
description The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity through regulation of oxidative stress. Bioinformatic analysis revealed RSK2 association with breast cancer risk and oral contraceptives.
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spelling pubmed-76710692020-11-23 RSK2 and ERα comrades-in-arms in homeostasis and transformation Ludwik, Katarzyna A. Lannigan, Deborah A. Mol Cell Oncol Commentary The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity through regulation of oxidative stress. Bioinformatic analysis revealed RSK2 association with breast cancer risk and oral contraceptives. Taylor & Francis 2020-11-01 /pmc/articles/PMC7671069/ /pubmed/33235919 http://dx.doi.org/10.1080/23723556.2020.1825916 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Ludwik, Katarzyna A.
Lannigan, Deborah A.
RSK2 and ERα comrades-in-arms in homeostasis and transformation
title RSK2 and ERα comrades-in-arms in homeostasis and transformation
title_full RSK2 and ERα comrades-in-arms in homeostasis and transformation
title_fullStr RSK2 and ERα comrades-in-arms in homeostasis and transformation
title_full_unstemmed RSK2 and ERα comrades-in-arms in homeostasis and transformation
title_short RSK2 and ERα comrades-in-arms in homeostasis and transformation
title_sort rsk2 and erα comrades-in-arms in homeostasis and transformation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671069/
https://www.ncbi.nlm.nih.gov/pubmed/33235919
http://dx.doi.org/10.1080/23723556.2020.1825916
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