Medulloblastoma cells resemble neuronal progenitors in their differentiation

Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is drive...

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Detalles Bibliográficos
Autores principales: Guo, Duancheng, Qu, Yanghui, Yang, Yijun, Yang, Zeng-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671073/
https://www.ncbi.nlm.nih.gov/pubmed/33235914
http://dx.doi.org/10.1080/23723556.2020.1810514
Descripción
Sumario:Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.

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