Medulloblastoma cells resemble neuronal progenitors in their differentiation

Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is drive...

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Detalles Bibliográficos
Autores principales: Guo, Duancheng, Qu, Yanghui, Yang, Yijun, Yang, Zeng-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671073/
https://www.ncbi.nlm.nih.gov/pubmed/33235914
http://dx.doi.org/10.1080/23723556.2020.1810514
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author Guo, Duancheng
Qu, Yanghui
Yang, Yijun
Yang, Zeng-Jie
author_facet Guo, Duancheng
Qu, Yanghui
Yang, Yijun
Yang, Zeng-Jie
author_sort Guo, Duancheng
collection PubMed
description Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.
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spelling pubmed-76710732020-11-23 Medulloblastoma cells resemble neuronal progenitors in their differentiation Guo, Duancheng Qu, Yanghui Yang, Yijun Yang, Zeng-Jie Mol Cell Oncol Author’s Views Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3. Taylor & Francis 2020-09-05 /pmc/articles/PMC7671073/ /pubmed/33235914 http://dx.doi.org/10.1080/23723556.2020.1810514 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Guo, Duancheng
Qu, Yanghui
Yang, Yijun
Yang, Zeng-Jie
Medulloblastoma cells resemble neuronal progenitors in their differentiation
title Medulloblastoma cells resemble neuronal progenitors in their differentiation
title_full Medulloblastoma cells resemble neuronal progenitors in their differentiation
title_fullStr Medulloblastoma cells resemble neuronal progenitors in their differentiation
title_full_unstemmed Medulloblastoma cells resemble neuronal progenitors in their differentiation
title_short Medulloblastoma cells resemble neuronal progenitors in their differentiation
title_sort medulloblastoma cells resemble neuronal progenitors in their differentiation
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671073/
https://www.ncbi.nlm.nih.gov/pubmed/33235914
http://dx.doi.org/10.1080/23723556.2020.1810514
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AT quyanghui medulloblastomacellsresembleneuronalprogenitorsintheirdifferentiation
AT yangyijun medulloblastomacellsresembleneuronalprogenitorsintheirdifferentiation
AT yangzengjie medulloblastomacellsresembleneuronalprogenitorsintheirdifferentiation

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