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Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2
[Image: see text] The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screen...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671100/ https://www.ncbi.nlm.nih.gov/pubmed/34778724 http://dx.doi.org/10.1021/acsptsci.0c00163 |
| _version_ | 1783610861634453504 |
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| author | Liu, Ke Zou, Rongfeng Cui, Wenqiang Li, Meiqing Wang, Xueying Dong, Junlin Li, Hongchun Li, Hongpei Wang, Peihui Shao, Ximing Su, Wu Chan, H. C. Stephen Li, Hongchang Yuan, Shuguang |
| author_facet | Liu, Ke Zou, Rongfeng Cui, Wenqiang Li, Meiqing Wang, Xueying Dong, Junlin Li, Hongchun Li, Hongpei Wang, Peihui Shao, Ximing Su, Wu Chan, H. C. Stephen Li, Hongchang Yuan, Shuguang |
| author_sort | Liu, Ke |
| collection | PubMed |
| description | [Image: see text] The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19. |
| format | Online Article Text |
| id | pubmed-7671100 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American
Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76711002020-11-17 Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2 Liu, Ke Zou, Rongfeng Cui, Wenqiang Li, Meiqing Wang, Xueying Dong, Junlin Li, Hongchun Li, Hongpei Wang, Peihui Shao, Ximing Su, Wu Chan, H. C. Stephen Li, Hongchang Yuan, Shuguang ACS Pharmacol Transl Sci [Image: see text] The outbreak of COVID-19 by the end of 2019 has posed serious health threats to humanity and jeopardized the global economy. However, no effective drugs are available to treat COVID-19 currently and there is a great demand to fight against it. Here, we combined computational screening and an efficient cellular pseudotyped virus system, confirming that clinical HDAC inhibitors can efficiently prevent SARS-CoV-2 and potentially be used to fight against COVID-19. American Chemical Society 2020-11-11 /pmc/articles/PMC7671100/ /pubmed/34778724 http://dx.doi.org/10.1021/acsptsci.0c00163 Text en © 2020 American Chemical Society https://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlThis is an open access article published under an ACS AuthorChoice License (https://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Liu, Ke Zou, Rongfeng Cui, Wenqiang Li, Meiqing Wang, Xueying Dong, Junlin Li, Hongchun Li, Hongpei Wang, Peihui Shao, Ximing Su, Wu Chan, H. C. Stephen Li, Hongchang Yuan, Shuguang Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2 |
| title | Clinical HDAC Inhibitors Are Effective Drugs to Prevent
the Entry of SARS-CoV2 |
| title_full | Clinical HDAC Inhibitors Are Effective Drugs to Prevent
the Entry of SARS-CoV2 |
| title_fullStr | Clinical HDAC Inhibitors Are Effective Drugs to Prevent
the Entry of SARS-CoV2 |
| title_full_unstemmed | Clinical HDAC Inhibitors Are Effective Drugs to Prevent
the Entry of SARS-CoV2 |
| title_short | Clinical HDAC Inhibitors Are Effective Drugs to Prevent
the Entry of SARS-CoV2 |
| title_sort | clinical hdac inhibitors are effective drugs to prevent
the entry of sars-cov2 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671100/ https://www.ncbi.nlm.nih.gov/pubmed/34778724 http://dx.doi.org/10.1021/acsptsci.0c00163 |
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