Normalizing single-cell RNA sequencing data with internal spike-in-like genes

Normalization with respect to sequencing depth is a crucial step in single-cell RNA sequencing preprocessing. Most methods normalize data using the whole transcriptome based on the assumption that the majority of transcriptome remains constant and are unable to detect drastic changes of the transcri...

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Detalles Bibliográficos
Autores principales: Lin, Li, Song, Minfang, Jiang, Yong, Zhao, Xiaojing, Wang, Haopeng, Zhang, Liye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671304/
https://www.ncbi.nlm.nih.gov/pubmed/33575610
http://dx.doi.org/10.1093/nargab/lqaa059

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