InMeRF: prediction of pathogenicity of missense variants by individual modeling for each amino acid substitution

In predicting the pathogenicity of a nonsynonymous single-nucleotide variant (nsSNV), a radical change in amino acid properties is prone to be classified as being pathogenic. However, not all such nsSNVs are associated with human diseases. We generated random forest (RF) models individually for each...

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Detalles Bibliográficos
Autores principales: Takeda, Jun-ichi, Nanatsue, Kentaro, Yamagishi, Ryosuke, Ito, Mikako, Haga, Nobuhiko, Hirata, Hiromi, Ogi, Tomoo, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671370/
https://www.ncbi.nlm.nih.gov/pubmed/33543123
http://dx.doi.org/10.1093/nargab/lqaa038

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