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Investigating the Potential of Phosphatidylcholine-Based Nano-Sized Carriers in Boosting the Oto-Topical Delivery of Caroverine: in vitro Characterization, Stability Assessment and ex vivo Transport Studies
PURPOSE: Drug delivery into the inner ear across the intact tympanic membrane (TM) has been a challenge in the treatment of inner ear disorders. In this study, nano-sized carriers were formulated for improving the non- invasive oto-topical delivery of caroverine for the treatment of tinnitus. METHOD...
Autores principales: | Farrah, Amira Yousry, Al-mahallawi, Abdulaziz M, Basalious, Emad B, Nesseem, Demiana I |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671472/ https://www.ncbi.nlm.nih.gov/pubmed/33223827 http://dx.doi.org/10.2147/IJN.S259172 |
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