Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

Loss of WRN, a DNA repair helicase, was identified as a strong vulnerability of microsatellite instable (MSI) cancers, making WRN a promising drug target. We show that ATP binding and hydrolysis are required for genome integrity and viability of MSI cancer cells. We report a 2.2-Å crystal structure...

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Detalles Bibliográficos
Autores principales: Newman, Joseph A, Gavard, Angeline E, Lieb, Simone, Ravichandran, Madhwesh C, Hauer, Katja, Werni, Patrick, Geist, Leonhard, Böttcher, Jark, Engen, John R, Rumpel, Klaus, Samwer, Matthias, Petronczki, Mark, Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671478/
https://www.ncbi.nlm.nih.gov/pubmed/33199508
http://dx.doi.org/10.26508/lsa.202000795

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