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A functional context for heterogeneity of the circadian clock in cells

Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as build...

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Detalles Bibliográficos
Autores principales: Merrow, Martha, Harrington, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671520/
https://www.ncbi.nlm.nih.gov/pubmed/33052900
http://dx.doi.org/10.1371/journal.pbio.3000927
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author Merrow, Martha
Harrington, Mary
author_facet Merrow, Martha
Harrington, Mary
author_sort Merrow, Martha
collection PubMed
description Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase.
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spelling pubmed-76715202020-11-19 A functional context for heterogeneity of the circadian clock in cells Merrow, Martha Harrington, Mary PLoS Biol Primer Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase. Public Library of Science 2020-10-14 /pmc/articles/PMC7671520/ /pubmed/33052900 http://dx.doi.org/10.1371/journal.pbio.3000927 Text en © 2020 Merrow, Harrington http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Merrow, Martha
Harrington, Mary
A functional context for heterogeneity of the circadian clock in cells
title A functional context for heterogeneity of the circadian clock in cells
title_full A functional context for heterogeneity of the circadian clock in cells
title_fullStr A functional context for heterogeneity of the circadian clock in cells
title_full_unstemmed A functional context for heterogeneity of the circadian clock in cells
title_short A functional context for heterogeneity of the circadian clock in cells
title_sort functional context for heterogeneity of the circadian clock in cells
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671520/
https://www.ncbi.nlm.nih.gov/pubmed/33052900
http://dx.doi.org/10.1371/journal.pbio.3000927
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