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A functional context for heterogeneity of the circadian clock in cells
Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as build...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671520/ https://www.ncbi.nlm.nih.gov/pubmed/33052900 http://dx.doi.org/10.1371/journal.pbio.3000927 |
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author | Merrow, Martha Harrington, Mary |
author_facet | Merrow, Martha Harrington, Mary |
author_sort | Merrow, Martha |
collection | PubMed |
description | Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase. |
format | Online Article Text |
id | pubmed-7671520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76715202020-11-19 A functional context for heterogeneity of the circadian clock in cells Merrow, Martha Harrington, Mary PLoS Biol Primer Characterization of circadian systems at the organism level—a top-down approach—has led to definition of unifying properties, a hallmark of the science of chronobiology. The next challenge is to use a bottom-up approach to show how the molecular workings of the cellular circadian clock work as building blocks of those properties. We review new studies, including a recently published PLOS Biology paper by Nikhil and colleagues, that show how programmed but also stochastic generation of variation in cellular circadian period explain important adaptive features of entrained circadian phase. Public Library of Science 2020-10-14 /pmc/articles/PMC7671520/ /pubmed/33052900 http://dx.doi.org/10.1371/journal.pbio.3000927 Text en © 2020 Merrow, Harrington http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Primer Merrow, Martha Harrington, Mary A functional context for heterogeneity of the circadian clock in cells |
title | A functional context for heterogeneity of the circadian clock in cells |
title_full | A functional context for heterogeneity of the circadian clock in cells |
title_fullStr | A functional context for heterogeneity of the circadian clock in cells |
title_full_unstemmed | A functional context for heterogeneity of the circadian clock in cells |
title_short | A functional context for heterogeneity of the circadian clock in cells |
title_sort | functional context for heterogeneity of the circadian clock in cells |
topic | Primer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671520/ https://www.ncbi.nlm.nih.gov/pubmed/33052900 http://dx.doi.org/10.1371/journal.pbio.3000927 |
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