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Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro

Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture of HeLa cells. The kinetic study showed that 3-de...

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Detalles Bibliográficos
Autores principales:	Grabowska, Ewa, Czerniecka, Magdalena, Czyżewska, Urszula, Zambrzycka, Aneta, Łotowski, Zenon, Tylicki, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671598/ https://www.ncbi.nlm.nih.gov/pubmed/33187452 http://dx.doi.org/10.1080/14756366.2020.1844681

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