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Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease

In a group of 208 patients with chronic ischaemic heart disease, the variation of A(2)-associated-LDL phosphatase (Lp-PLA(2)) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA(2) can be accepted...

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Autores principales: Diaconu, Adriana, Coculescu, Bogdan-Ioan, Manole, Gheorghe, Vultur, Horațiu, Coculescu, Elena Claudia, Stocheci, Cristina Maria, Tudorache, Ioan-Sorin, Dincă, Alexandra-Ligia, Dincă, Valeriu Gabi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671608/
https://www.ncbi.nlm.nih.gov/pubmed/33187461
http://dx.doi.org/10.1080/14756366.2020.1839447
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author Diaconu, Adriana
Coculescu, Bogdan-Ioan
Manole, Gheorghe
Vultur, Horațiu
Coculescu, Elena Claudia
Stocheci, Cristina Maria
Tudorache, Ioan-Sorin
Dincă, Alexandra-Ligia
Dincă, Valeriu Gabi
author_facet Diaconu, Adriana
Coculescu, Bogdan-Ioan
Manole, Gheorghe
Vultur, Horațiu
Coculescu, Elena Claudia
Stocheci, Cristina Maria
Tudorache, Ioan-Sorin
Dincă, Alexandra-Ligia
Dincă, Valeriu Gabi
author_sort Diaconu, Adriana
collection PubMed
description In a group of 208 patients with chronic ischaemic heart disease, the variation of A(2)-associated-LDL phosphatase (Lp-PLA(2)) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA(2) can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.
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spelling pubmed-76716082020-11-23 Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease Diaconu, Adriana Coculescu, Bogdan-Ioan Manole, Gheorghe Vultur, Horațiu Coculescu, Elena Claudia Stocheci, Cristina Maria Tudorache, Ioan-Sorin Dincă, Alexandra-Ligia Dincă, Valeriu Gabi J Enzyme Inhib Med Chem Research Paper In a group of 208 patients with chronic ischaemic heart disease, the variation of A(2)-associated-LDL phosphatase (Lp-PLA(2)) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA(2) can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy. Taylor & Francis 2020-11-13 /pmc/articles/PMC7671608/ /pubmed/33187461 http://dx.doi.org/10.1080/14756366.2020.1839447 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Diaconu, Adriana
Coculescu, Bogdan-Ioan
Manole, Gheorghe
Vultur, Horațiu
Coculescu, Elena Claudia
Stocheci, Cristina Maria
Tudorache, Ioan-Sorin
Dincă, Alexandra-Ligia
Dincă, Valeriu Gabi
Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title_full Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title_fullStr Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title_full_unstemmed Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title_short Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
title_sort lipoprotein-associated phospholipase a2 (lp-pla2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671608/
https://www.ncbi.nlm.nih.gov/pubmed/33187461
http://dx.doi.org/10.1080/14756366.2020.1839447
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