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Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats

BACKGROUND: Deletion or mutations of SHANK3 lead to Phelan–McDermid syndrome and monogenic forms of autism spectrum disorder (ASD). SHANK3 encodes its eponymous scaffolding protein at excitatory glutamatergic synapses. Altered morphology of dendrites and spines in the hippocampus, cerebellum, and st...

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Detalles Bibliográficos
Autores principales:	Jacot-Descombes, Sarah, Keshav, Neha U., Dickstein, Dara L., Wicinski, Bridget, Janssen, William G. M., Hiester, Liam L., Sarfo, Edward K., Warda, Tahia, Fam, Matthew M., Harony-Nicolas, Hala, Buxbaum, Joseph D., Hof, Patrick R., Varghese, Merina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671669/ https://www.ncbi.nlm.nih.gov/pubmed/33203459 http://dx.doi.org/10.1186/s13229-020-00393-8

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