The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication stress and in the ensuing recovery period to promote cell survival. Of two isoforms produced by alternati...

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Detalles Bibliográficos
Autores principales: Watts, Lotte P, Natsume, Toyoaki, Saito, Yuichiro, Garzon, Javier, Dong, Qianqian, Boteva, Lora, Gilbert, Nick, Kanemaki, Masato T, Hiraga, Shin-ichiro, Donaldson, Anne D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671687/
https://www.ncbi.nlm.nih.gov/pubmed/33141022
http://dx.doi.org/10.7554/eLife.58020

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