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Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis

Coronavirus disease 2019 (COVID-19) is a new zoonotic infectious disease that was first reported to the World Health Organization (WHO) on December 31, 2019, and declared as a pandemic by WHO on March 11, 2020. Due to the increased incidence of multimorbidity in geriatric age groups, COVID-19 diseas...

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Autores principales: Görgülü, Özkan, Duyan, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671936/
https://www.ncbi.nlm.nih.gov/pubmed/33225222
http://dx.doi.org/10.1007/s42399-020-00645-x
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author Görgülü, Özkan
Duyan, Murat
author_facet Görgülü, Özkan
Duyan, Murat
author_sort Görgülü, Özkan
collection PubMed
description Coronavirus disease 2019 (COVID-19) is a new zoonotic infectious disease that was first reported to the World Health Organization (WHO) on December 31, 2019, and declared as a pandemic by WHO on March 11, 2020. Due to the increased incidence of multimorbidity in geriatric age groups, COVID-19 disease leads to more severe consequences in the elderly. We aimed to determine the effects of age, comorbidity factors, symptoms, laboratory findings, and radiological results on prognosis by dividing our patients into 3 different geriatric age groups, using a retrospective descriptive analysis method. Patients included in the retrospective study (n = 483) were divided into the following three different geriatric age groups: young-old (65–74 years), middle-aged (75–84 years), and the oldest-elderly (85 years and over).The length of stay in the intensive care unit of the patients between the ages of 75–84 was higher than the other two groups (p = 0.013). Mortality rates were lowest in patients aged 65–74 years (p < 0.001). The rate of ground glass opacity in thorax CT was higher in patients with mortality (p < 0.001). While the rate of COPD-bronchial asthma was higher in surviving patients (p = 0.001), malignancy (p = 0.005) and cerebrovascular disease (p < 0.001) were higher in patients who died. Patients aged between 75 and 84 (OR: 2.602; 95% CI: 1.306–5.183; p = 0.007) or ≥ 85 (OR: 4.086; 95% CI: 1.687–9.9; p = 0.002) had higher risk for mortality compared to patients aged between 65 and 74. The lowest mortality rates were observed in patients aged 65–74 years. Among the supportive diagnostic methods in 3 different geriatric age groups, PCR positivity has no effect on mortality, while the ground glass opacity on tomography is closely related to the need for intensive care and increased mortality. In patients with COPD-bronchial asthma comorbidity and those with symptoms of fatigue, dry cough, and sore throat, transfer to intensive care and mortality rates were lower, while patients who were transferred to intensive care and who developed mortality had higher malignancy and cerebrovascular disease comorbidities and dyspnea symptoms.
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spelling pubmed-76719362020-11-18 Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis Görgülü, Özkan Duyan, Murat SN Compr Clin Med Covid-19 Coronavirus disease 2019 (COVID-19) is a new zoonotic infectious disease that was first reported to the World Health Organization (WHO) on December 31, 2019, and declared as a pandemic by WHO on March 11, 2020. Due to the increased incidence of multimorbidity in geriatric age groups, COVID-19 disease leads to more severe consequences in the elderly. We aimed to determine the effects of age, comorbidity factors, symptoms, laboratory findings, and radiological results on prognosis by dividing our patients into 3 different geriatric age groups, using a retrospective descriptive analysis method. Patients included in the retrospective study (n = 483) were divided into the following three different geriatric age groups: young-old (65–74 years), middle-aged (75–84 years), and the oldest-elderly (85 years and over).The length of stay in the intensive care unit of the patients between the ages of 75–84 was higher than the other two groups (p = 0.013). Mortality rates were lowest in patients aged 65–74 years (p < 0.001). The rate of ground glass opacity in thorax CT was higher in patients with mortality (p < 0.001). While the rate of COPD-bronchial asthma was higher in surviving patients (p = 0.001), malignancy (p = 0.005) and cerebrovascular disease (p < 0.001) were higher in patients who died. Patients aged between 75 and 84 (OR: 2.602; 95% CI: 1.306–5.183; p = 0.007) or ≥ 85 (OR: 4.086; 95% CI: 1.687–9.9; p = 0.002) had higher risk for mortality compared to patients aged between 65 and 74. The lowest mortality rates were observed in patients aged 65–74 years. Among the supportive diagnostic methods in 3 different geriatric age groups, PCR positivity has no effect on mortality, while the ground glass opacity on tomography is closely related to the need for intensive care and increased mortality. In patients with COPD-bronchial asthma comorbidity and those with symptoms of fatigue, dry cough, and sore throat, transfer to intensive care and mortality rates were lower, while patients who were transferred to intensive care and who developed mortality had higher malignancy and cerebrovascular disease comorbidities and dyspnea symptoms. Springer International Publishing 2020-11-18 2020 /pmc/articles/PMC7671936/ /pubmed/33225222 http://dx.doi.org/10.1007/s42399-020-00645-x Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Görgülü, Özkan
Duyan, Murat
Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title_full Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title_fullStr Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title_full_unstemmed Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title_short Effects of Comorbid Factors on Prognosis of Three Different Geriatric Groups with COVID-19 Diagnosis
title_sort effects of comorbid factors on prognosis of three different geriatric groups with covid-19 diagnosis
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671936/
https://www.ncbi.nlm.nih.gov/pubmed/33225222
http://dx.doi.org/10.1007/s42399-020-00645-x
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